David A. Brafman

Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder influenced by both causal mutations and genetic modifiers. The rare APOE3 Christchurch (APOE3ch) variant has been associated with delayed disease onset in a familial Alzheimer’s disease case, suggesting a potential protective role. However, the me...