Parkinson's disease (PD) and related -synucleinopathies are defined by the spread of Lewy body (LB) pathology across vulnerable brain regions, yet how substantia nigra (SN) myeloid cells respond remains unresolved. Using SOX10-based oligodendrocyte depletion and CD11b-based myeloid enrichment, we profiled 169,799 brain...
Raphael Kübler, Daniele Mattei, J. O. Narcís et al.· medRxiv· 0 citations
Broad utility is demonstrated: identifying context-specific regulators of p53 under ribosomal stress, characterizing dose-dependent drug mechanisms of action, and uncovering cytokine-driven B cell heterogeneity during secondary influenza infection in vivo are demonstrated.
Isabella N. Grabski, Junsuk Lee, John D. Blair et al.· Cell· 0 citations
SUMMARY
Most human genes produce multiple RNA isoforms, yet it remains unclear which isoforms are translated into stable, functional proteins. Long-read RNA sequencing resolves full-length transcript structures and, when paired with mass spectrometry, can provide empirical evidence of isoform translation. Despite this...
Megan D. Schertzer, Julia T. Lewandowski, Emily F. Watts et al.· Bioinformatics· 0 citations
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