Author

David Baker

3 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Sep 2026

De Novo Design and Structural Optimization of Mn(salen)‐Based Artificial Metalloenzymes for Asymmetric Sulfoxidation

ABSTRACT Artificial metalloenzymes (ArMs) exhibit exceptional selectivity, yet extending their reactivity beyond native cofactors remains a major challenge. While previous designs using native protein scaffolds to incorporate nonnative cofactors have been reported, de novo protein design enables tailored scaffolds that...

Jing-Xiang Wang, Yun-Ling Deng, Indrek Kalvet et al. · Angewandte Chemie · 0 citations

Open access Sep 2026

Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression.

Phagocytic synapse enhancers are developed, a class of modular immune engagers comprising a high-affinity PD-L1 binder coupled to a macrophage-stimulating peptide, tuftsin, that provides a blueprint for a plug-and-play platform of immune engagers targeting diverse cancer-associated pathways.

Valerio Sabatino, Cong Tang, Rita C. Acúrcio et al. · Cancer Research · 0 citations

Open access Aug 2026

Enhancing De Novo Designed Peptides and Proteins via Irreversible Covalent Isoquinolinium Capture

Irreversible covalent inhibitors have garnered significant attention in recent years. Despite encouraging progress, the vast majority contain electrophiles that target the least abundant amino acid cysteine, substantially limiting target inhibitor design for therapeutic intervention. Here, we generalize 2-ethynylbenzal...

Paul M. Levine, Patrick W. Erickson, Timothy W. Craven et al. · ACS Chemical Biology · 0 citations