Author

David Chen

2 papers indexed here

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Open access Aug 2026

Plasma proteomics defines two reproducible subphenotypes of sepsis-associated acute kidney injury with distinct outcomes

Sepsis is the leading cause of acute kidney injury in critically ill patients, and this complication carries a high risk of death. The biology underlying it varies between patients, which may explain why treatments have not succeeded. Here we show, using an ensemble method that groups patients by patterns across hundre...

M. Legrand, H. Nguyen, C. Calfee et al. · Nature Communications · 0 citations

Aug 2026

Early Surgery and Outcomes in Severe Burns: A Prospective Multicenter Observational Study.

OBJECTIVE To examine the association between the timing of surgical excision and survival in severely ill burn patients. SUMMARY BACKGROUND DATA The optimal timing of surgical excision in severe burns remains uncertain. Early excision may limit systemic inflammation but may also increase hemodynamic instability. ME...

Matthieu Legrand, C. Hoffmann, A. Roquilly et al. · Annals of Surgery · 1 citation