Biomolecular reactions are often composed of multiple stochastic, reversible and branched transition paths over intermediates, leading to rich dynamics. Single-molecule biophysics has revolutionized our view of biology by revealing the heterogeneity in realized paths and pointing to the importance of rare events. The r...
Pim P. B. America, Misha Klein, David Dulin et al.· bioRxiv· 0 citations
RfaH, a NusG paralog recruited at ops and essential for long virulence operons, loads onto ops-paused RNAP by two pathways: one permitting immediate escape, the other requiring GreA rescue, which provides the foundation for dissecting virulence operon expression and its therapeutic targeting.
Luca Buccolieri, Bing Wang, Pim P. B. America et al.· bioRxiv· 0 citations
A full-length, membrane-associated model supports a role for NS3 as a candidate membrane-spanning RNA translocase that may couple ATP hydrolysis to genome movement and establishes a basis for mechanistic studies and structure-guided antiviral design.
Meryl Haas, T. Hoeksma, J. Mills et al.· Nature Communications· 0 citations
These findings establish a two-pronged mode of coronavirus polymerase inhibition by CMX521, and suggest a second inhibitory mechanism for CMX521 when the coronavirus polymerase is associated with the viral helicase.
Asif Rakib, Calvin J. Gordon, Thomas K. Anderson et al.· Journal of Biological Chemis...· 0 citations
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