Granzyme B (GzmB) is a serine protease traditionally recognized for its role in lymphocyte-mediated apoptosis. In specific conditions, GzmB accumulates in the extracellular milieu and retains its proteolytic activity, cleaving extracellular proteins thereby contributing to disease progression. Nevertheless, pathologica...
A. Aubert, A. Prudova, Jeffrey S. Tang et al.· Matrix Biology· 0 citations
Neuroinflammation is a central driver of numerous neurological disorders. While granzymes have classically been studied as cytotoxic effector molecules secreted from immune cells along with the pore-forming molecule, perforin, accumulating evidence suggests that these serine proteases also play roles in non-cytotoxic...
Daniele P. Ferrari, J. Sidhu, Karen Jung et al.· Cellular and molecular neuro...· 0 citations
Granzymes (Gzms) are a family of serine proteases that have been traditionally studied as cytotoxic mediators of lymphocyte-mediated target cell death. However, increasing evidence suggests that during inflammation Gzms can accumulate in the extracellular milieu and contribute to various pathologies depending on the...
K. Richardson, Jeffrey S. Tang, A. Aubert et al.· Cell Death & Disease· 0 citations
GzmB is the most extensively characterized, with evidence supporting both intracellular neurotoxicity and extracellular pathogenic functions mediated through protease-activated receptor signaling, ECM cleavage, outer blood–retina barrier disruption, angiogenesis, fibrosis, and chronic inflammation.
Hyung-Suk Yoo, Philip Yu, Ceres Zhou et al.· Acta Neuropathologica· 0 citations
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