Author

David M. Holtzman

2 papers indexed here

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Open access Sep 2026

Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome.

There was no evidence of astrogliosis after microglia ablation as determined by proteome analysis and brain histology, crucial for interpreting changes to the CSF proteome in relation to neuroinflammatory changes in neurological diseases.

S. Büchner, Si-Hui Song, Stephan A. Müller et al. · Proteomics · 0 citations

Open access Sep 2026

The sphingosine-1-phosphate receptor functional antagonist fingolimod exacerbates neuroinflammation and tau pathology in a mouse model of tauopathy

Objective T cells are increased in the brain in Alzheimer’s disease (AD) and primary tauopathies where they correlate with tau pathology. In mouse models, T cells exacerbate tau-related neuroinflammation and neurodegeneration, and depletion of T cells is neuroprotective. Here, we investigate whether the multiple sclero...

M. Rudman, Alexandra Litvinchuk, Cathryn Smith et al. · bioRxiv · 0 citations