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Defining the role of continued antigen engagement in regulating tumor-specific CD8+ T cell differentiation, migration, and survival 2256732
Understanding of the development of T cell exhaustion and the plasticity of lineage commitment in cancer to better inform future anti-cancer therapeutics is added.
Robust T Cell Activation Kills Tumors Regardless of T Cell Specificity 2260126
Triggering productive T cell activation within tumors can be sufficient for immunotherapy, without needing to induce or rescue cancer-specific responses.