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Author

David P. Labbé

2 papers indexed here

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Open access Sep 2026

EZH2-dependent phenotypic plasticity reveals TTP-associated and mTORC1 therapeutic vulnerabilities in lethal prostate cancer.

Phenotypic plasticity is a recognized mechanism of therapeutic resistance in prostate cancer (PCa); however, current knowledge of its underlying drivers and therapeutic interventions remain limited. Using genetically engineered mouse models (GEMMs) devoid of Pten and Rb1, we previously demonstrated the chromatin reprog...

Beatriz German, K. Morel, Teia Noel et al. · 0 citations
Review Jul 2026

From Tissue Specificity to Systemic Cues: Shaping MYC‑Driven Tumor Metabolism.

The proto-oncogene MYC acts as a master regulator of diverse metabolic programs that fuel tumor initiation and progression, but the exact programs it activates depend heavily on context, tissue type, accompanying mutations, and the tumor microenvironment (TME). Furthermore, extrinsic influences, including diet and syst...

A. Alamoudi, Yiming Mao, G. Zadra et al. · 0 citations

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