Changes in intracellular pH are critical for maintaining homeostasis, mediating signaling pathways, and enabling cellular responses to stress, injury, and disease. There is increasing evidence that clusters of acidic residues, primarily glutamates, are both highly prevalent and conserved in disordered regions of protei...
A. M. Whited, Patrick DeLear, Ezekiel C. Thomas et al.· bioRxiv· 0 citations
The theoretical, computational and cultural challenges that need to be overcome to gain an understanding of the biological mesoscale are described and potential solutions are offered.
Sarah Harris, Gianluca Lattanzi, Angelo Rosa et al.· Biophysical Journal· 0 citations
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