Author

D. Sergeevichev

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Review Open access Oct 2026

Senescence and SASP in the Stromal Microenvironment of Breast Cancer: Dual Role in Progression and Therapeutic Options.

Cellular senescence, a process characterized by the typically persistent cell-cycle arrest that occurs in response to DNA damage, plays a dual role in carcinogenesis. This complexity is predominantly influenced by the presence of senescent cancer-associated fibroblasts within the tumor microenvironment. While the induc...

Maria Bogachek, David Sergeevichev, A. Leonteva et al. · Aging and Disease · 0 citations

Open access Sep 2026

Stromal Remodeling of the Cytokine Secretome Reveals a Chemokine Core Across Breast Cancer and Glioma 3D Cell Culture Models

Mounting evidence indicates that the tumor microenvironment plays a decisive role in cancer progression. However, the quantitative assessment of how individual stromal components contribute to cytokine secretion in 3D models remains poorly understood, especially when comparing tumours of different origins. The developm...

David Sergeevichev, A. Leonteva, Alina Kazakova et al. · Cells · 0 citations

Open access Jul 2026

Reconstructing the glioblastoma microenvironment in heterotypic 3D spheroids: a multicellular model to study tumor-stromal crosstalk

These heterotypic 3D spheroid models offer a stroma-enriched, reproducible platform for the analysis of stromal contributions to glioma progression and for exploratory preclinical evaluation of therapeutic strategies.

Y. Nikitina, Alina Kazakova, A.A. Leonteva et al. · Frontiers in Bioengineering... · 0 citations