Author

David W. C. MacMillan

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Open access Aug 2026

Mesoscale proximity labeling at chromatin leads to identification of small molecule mechanism of action

Proximity labeling typically identifies interactomes of single protein or RNA baits, limiting its use for mechanisms distributed across molecular systems. Here, we establish MesoMap, a chromatin-focused mesoscale proximity-labeling strategy that installs nanoscale photocatalysts on multiple histone baits to monitor dru...

Cameron J. Douglas, Preston N. Samowitz, Fei-Fei Tong et al. · Nature Communications · 0 citations

Open access Aug 2026

Mutant p53 gains RNA-binding activity to reprogram translation and mitochondrial function

SUMMARY Tumor suppressor p53 is a transcription factor mutated in ~50% of cancers. Somatic mutations in the DNA-binding domain abolish tumor suppression and thus lead to a loss-of-function activity, while a small subset of recurrent “hotspot” mutants have been shown to confer gain-of-function activities. Using an intei...

Wuyue Zhou, Alice Long, Cameron J. Douglas et al. · Cell Reports · 0 citations