Author

David W. J. Mcquarrie

2 papers indexed here

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Open access Sep 2026

LARP1-DM15/Sgt is a reader for cap-adjacent 2’-O-ribose methylation in TOP ribosomal protein mRNAs required for localization to synapses

The most prominent mRNA modification in animals and many of their parasites is 2’-O-ribose methylation of cap-adjacent nucleotides (cOMe) introduced by cap-methyl transferases (CMTrs). How these modifications impact on gene expression and are decoded by reader proteins, however, remains uncertain. Through analysis of t...

Yuan W. Tian, Yavor Hadzhiev, G. Abis et al. · bioRxiv · 0 citations

Open access Aug 2026

Multimerization of ELAV in Drosophila is essential for directing neuronal alternative splicing and polyadenylation programs.

X-ray crystal structures of ELAV RNA recognition motif 3 (RRM3) are determined to reveal that multimerization is mediated by two evolutionarily conserved interfaces in non-RNA-binding parts of the RRM to form a tetramer and RNA binding is not required for multimerization.

Thomas C. Dix, David W. J. Mcquarrie, Ulrike Bräuer et al. · Genes & Development · 0 citations