Open access
Sep 2026
Modular assembly and property profiling of an expansive, shape-defined library of pentacyclic saturated N-heterocycles
The design, iterative synthesis, and comprehensive property profiling of a novel chemical library of shape-defined, morpholine-containing pentacycles revealed promising drug-like properties, including broad aqueous solubility, metabolic stability, low cytochrome P450 inhibition, and tunable membrane permeability.
E. Boschi, Dmitry Mazunin, Alex Mueller et al.
· Chemical Science · 0 citations