RATIONALE & OBJECTIVE
Angiopoietin-like proteins (ANGPTL) 3 and 4 modulate lipoprotein metabolism through inhibition of lipases. Reduced activity of ANGPTL3 and ANGPTL4 improves kidney function in mice. This study aimed to investigate the causal relationships of ANGPTLs and their lipase targets with chronic kidney dise...
Guo-Yi Yang, David Y. Zhang, Clara J. Fischman et al.· American Journal of Kidney D...· 0 citations
Linkage disequilibrium (LD) information from one’s own dataset is considered optimal for downstream analyses such as statistical fine-mapping. However, the computational complexity ( computations for N variants) lead most studies to use external reference panels, such as from 1000 Genomes. To capture LD across all vari...
Rachit Kumar, Pankhuri Singhal, David Y. Zhang et al.· bioRxiv· 0 citations
It is shown that ML models integrating biliary-disease associated health records and Gamma glutamyltransferase can stratify risk of future CCA, and demonstrates the potential of data-driven models in personalised screening for hepatobiliary cancer.
F. van Haag, J. Clusmann, Paul-Henry Koop et al.· EBioMedicine· 0 citations
This represents the most comprehensive characterization to date of TRND, a novel neurodevelopmental disorder, defining its genotypic and phenotypic spectrum.
Sally Nijim, Mimi Kim, Melissa Denish et al.· Genetics in Medicine· 1 citation
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