De-Min Wang

NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice

Oxidative stress and genotoxic damage activate NF-κB signaling through intracellular pathways distinct from those initiated by membrane receptors. DNA damage selectively induces post-translational modifications at lysine residues 277 and 309 of the human ubiquitin-binding protein NEMO to promote NF-κB signaling, but th...