De-Ping Kong

RBM6 Facilitates RLR-Mediated Antiviral Responses by Promoting K63-Linked Ubiquitination of MAVS.

The mitochondrial antiviral signaling protein (MAVS; also known as VISA, IPS-1, or Cardif) is the central adaptor of the RIG-I-like receptor (RLR) pathway. Upon viral infection, MAVS forms prion-like aggregates to activate NF-κB and IRF3, thereby inducing type I interferon production and antiviral responses. Here, we i...