Author

De-Qiang Wang

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Open access Sep 2026

Histone H3K18 Lactylation Drives Immunosuppression by Upregulating CD38 in Myeloid-Derived Suppressor Cells in Lung Cancer.

Histone lactylation is an epigenetic modification that connects lactate metabolism with protein function. Our study identified lactate enhances the protein lactylation level not only in Myeloid-derived suppressor cells (MDSCs) of tumor-bearing mice, but also in the tumor tissues of lung cancer patients. This modificati...

Yao Dai, Hai-Yan Dai, Ya-Hui Wang et al. · Cancer immunology research · 0 citations

Review Open access Aug 2026

Unraveling the Multifaceted Role of TRIM21 in Virus-Triggered Innate Immunity and Diseases

Tripartite motif-containing protein 21 (TRIM21/Ro52) is a pivotal E3 ubiquitin ligase and cytoplasmic fragment crystallizable receptor (FcR). It plays a crucial role in viral infections, autoimmune disorders, and cancers by regulating multiple cell signaling axes, including the NF-κB, RIG-I-like receptor (RLR), cGAS-ST...

Shi-Jin Lan, Ying Wang, Yu-Tong Fu et al. · Biomolecules · 0 citations