Injectable ECM-mimetic dynamic Schiff-base hydrogels deliver 5-aminosalicylic acid for immunomodulatory and alleviation of ferroptosis-associated injury of intervertebral disc degeneration.
Intervertebral disc degeneration (IDD) is driven by persistent inflammation, macrophage dysregulation, and ferroptosis-associated injury of nucleus pulposus cells (NPCs). Here, we developed an acid-responsive injectable hydrogel based on oxidized chondroitin sulfate and adipic acid dihydrazide-modified hyaluronic acid...