De-Sheng Wang

Enantioselective Synthesis of gem -Difluorinated Spirobenzazepinoindoles by Chiral Phosphoric Acid (CPA)-Catalyzed Asymmetric Pictet–Spengler Cyclization

7-membered spirobenzazepinoindole frameworks constitute an important family of heterocyclic skeletons with broad utility in pharmaceutical research. Despite their value, the stereoselective synthetic routes toward chiral gem-difluorinated spirobenzazepinoindoles remain unexplored, and a general, efficient constructio...