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De-Xian Li

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Open access Sep 2026

Limonin ameliorates hyperuricemia-induced cognitive impairment through modulation of microglial HIF-1α-driven neuroinflammation.

BACKGROUND Hyperuricemia (HUA), a highly prevalent metabolic disorder, is increasingly linked to cognitive impairment. Limonin (LIM), a natural compound with anti-inflammatory and neuroprotective properties, has the therapeutic benefits, but its underlying mechanisms remain unclear. PURPOSE This study aimed to invest...

Jie Chen, De-Xian Li, Xiao-Hu Chen et al. · 0 citations

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