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De-Yu Zhang

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Aug 2026

Diastereo- and Enantioselective Synthesis of 9-Aryl-1-vinyl-tetrahydro-β-carbolines via Brønsted Acid-Catalyzed Pictet-Spengler Reaction.

Reported herein is a stereoselective synthesis of 9-aryl-1-vinyl-tetrahydro-β-carbolines via a Pictet-Spengler reaction. This reaction proceeds via Brønsted acid-catalyzed cyclization of N-indole-tethered allenamides with >20:1 dr under mild conditions, while chiral phosphoric acid catalysis installs the C-N axial chir...

De-Yu Zhang, Min Chen · 0 citations

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