Dynamic imbalance of mitochondria-associated ER membranes in cardiovascular disease: mechanisms, context dependence and therapeutic potential
Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic contact sites that coordinate structural and functional communication between the endoplasmic reticulum (ER) and mitochondria. By organizing tethering complexes, calcium channels, lipid-transfer machinery, and stress-responsive signaling modules...