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Author

Dean A Lee

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Sep 2026

Abstract A002: Epigenetic Regulation of the GDF15 Immune Checkpoint Determines Sensitivity of Atypical Teratoid/Rhabdoid Tumors to Natural Killer Cell Immunotherapy

Atypical teratoid/rhabdoid tumors (ATRTs) are highly aggressive pediatric central nervous system malignancies characterized by poor clinical outcomes despite intensive multimodal therapy, including surgery, chemotherapy, and radiation. Although molecular classification has improved our understanding of ATRT biology,...

V. Gopalakrishnan, Jyothishmathi Swaminathan, Ben Ho et al. · 0 citations
Jul 2026

Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22.

A trispecific CAR targeting CD19, CD20, and CD22 with OX40 co-stimulatory domain with overall response rate was 50%, including complete responses in 83% of lymphoma patients, and one-year overall survival rate was 61%, with durable remissions observed in lymphoma.

S. Vasu, N. Denlinger, No-Joon Song et al. · 0 citations

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