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Author

Debarghya Mitra

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Open access Sep 2026

Conformationally restrained de novo peptides to modulate Skp1-Skp2 interaction of the SCF E3 ligase.

De novo peptide sequences are introduced through in silico screening of a peptide pool to target the Skp1-Skp2 core interface and establish the potential of first-in-class peptides in targeting the Skp1-Skp2 interface for the treatment of cancers driven by Skp2.

Simran Tolani, N. M. Tripathi, H. Antil et al. · 1 citation
Open access Jul 2026

A Charge-Encoded Rheostat Permits Helix Nucleation but Limits Propagation in Skp1

The findings suggest that charged- hydrophobic-charged sequence patterning can encode conditional, context-dependent structure as a general organisational principle in intrinsically disordered proteomes.

D. Mitra, Simran Tolani, Amrita Bhattacharya et al. · 0 citations

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