Aug 2026
A Single Substitution of Valine to Glutamic Acid in the Omega-Like Loop Introduces a Penicillinase-Like Activity in MSMEG_6194 by Compromising its Role as DD-Carboxypeptidase
Findings suggest that MSMEG_6194 act as a DD-carboxypeptidase and illustrate how a single amino acid change can alter catalytic preference, shedding light on the evolutionary transition from DD-carboxypeptidases to beta-lactamases in mycobacteria.
Aditya Prasad Panda, Debasmita Chatterjee, Anik Roy et al.
· Current Microbiology · 0 citations