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Author

Debdeep Dutta

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Review Open access Oct 2026

The emerging role of ER-localized TMEM proteins in neurodevelopmental disorders.

Neurodevelopmental disorders (NDDs) comprise a spectrum of conditions that impair brain development and nervous system function, resulting in lifelong cognitive, behavioral, and motor disabilities. Globally, more than 3% of children are affected by NDDs. Although advances in next-generation sequencing technology have i...

Shreni Priyadarshini, Rishi Kumar, Debdeep Dutta · 0 citations
Open access Jul 2026

Epilepsy-associated digenic variants affecting an actin/mitochondria/glutamate pathway promote seizure susceptibility

The AMG pathway is established as a mechanistic framework for identifying digenic etiologies in epilepsy and highlight potential therapeutic targets after it was demonstrated that reduced actin polymerization promoted DRP1-mediated mitochondrial fission, increased ROS levels, and enhanced glutamatergic transmission, le...

Shenzhao Lu, Mengqi Ma, Shabab B. Hannan et al. · 0 citations

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