Author

Déborah Bourc'his

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Open access Sep 2026

Transposable Element insertions Repurpose Immune Endonucleases as Drivers of Reproductive Isolation in Mice

The emergence of reproductive barriers between closely related populations is a fundamental step in speciation, yet the underlying genetic mechanisms remain poorly understood in mammals. Here we resolve the DDK syndrome, a long-standing model of hybrid incompatibility in mice, by showing that two independent retrotrans...

Tabitha Rücker, S. Vandormael-Pournin, Joris Mordier et al. · bioRxiv · 0 citations

Open access Aug 2026

Simultaneous single-cell profiling of chromatin, transcriptome and surface markers with OneCell CUT&Tag captures epigenomic reprogramming.

This approach uncovers epigenomic priming of basal cells in the mammary gland and captures the dynamics of basal-to-luminal transdifferentiation, suggesting that epigenomic and transcriptional remodeling do not occur in complete synchrony during cell-fate conversion.

Anna Schwager, Eve Moutaux, Adeline Durand et al. · Nature Biotechnology · 0 citations