DoE-oriented optimization of a chitosan-based nanoemulgel of clobetasol propionate for therapeutic intervention in psoriasis
Psoriasis is an inflammatory skin disease caused by immune-mediated inflammation. Clobetasol propionate (Cp), a steroid, reduces inflammation by binding the glucocorticoid receptor. This study aimed to optimize a Cp-loaded nanoemulsion (Cp-NE) with a focus on its cytocompatibility with HaCaT keratinocytes and physicoch...