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Author

Deepa Waghray

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Open access Sep 2026

Structural basis of stepwise G protein activation by the viral chemokine receptor US28

G protein-coupled receptors (GPCRs) govern diverse cellular responses and are crucial drug targets. However, the sequence of structural events from G protein recognition to GDP release has remained elusive. Here, we leveraged the viral chemokine GPCR US28 to capture multiple activation states of the US28-Gq complex. Us...

K. Jude, Carl-Mikael Suomivuori, Deepa Waghray et al. · 0 citations

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