Deng-Ju Li

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

ABSTRACT Bruton's tyrosine kinase (BTK) is a nonreceptor tyrosine kinase that couples B‐cell receptor (BCR) signaling to broader immune‐cell activation. By integrating signals from BCR, Toll‐like receptors, chemokine receptors, Fc receptors, and BAFF receptors, BTK governs B‐cell development, immune‐cell migration, inn...