Serglycin-ROS axis mediates synergistic lethality of PI3Kγ inhibition and Azacitidine in TP53-mutated AML.
PURPOSE To investigate novel combination strategies for TP53-mutated acute myeloid leukemia (AML), focusing on the potential synergy between PI3Kγ inhibition and Azacitidine, and to elucidate the underlying molecular mechanisms. MATERIALS AND METHODS We detected the expression of PI3Kγ (PIK3CG/PIK3R5) in TP53 mutant...