Open access
Oct 2026
Nucleoporin 50 rescues hallmarks of TDP-43 proteinopathy in ALS/FTD disease models
Nuclear depletion and cytoplasmic aggregation of RNA-binding protein TDP-43 are common neuropathological hallmarks of the amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD) disease spectrum. Although defects in nucleocytoplasmic transport are well-documented in ALS/FTD disease models and patient...
Courtney L. Smith, Bilal Khalil, Alyssa C. Walker et al.
· Molecular Neurodegeneration · 0 citations