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Author

Derek M. Huffman

2 papers indexed here

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Open access Oct 2026

A new epigenetic framework for DNA methylation, hydroxymethylation, and gene expression during brain aging

DNA modifications are epigenetic marks added directly to DNA bases that can stably or dynamically regulate gene expression, allowing cells to maintain their identity while also having flexibility to adapt to changes in their environment1. Aging is often thought to disrupt this regulation, causing cells to lose their id...

Sarah R. Ocañas, Walker Hoolehan, Kevin Pham et al. · 0 citations
Open access Aug 2026

The glycine N-methyltransferase amino-terminus regulates folate-dependent feedback inhibition and S-adenosylmethionine homeostasis

Maintenance of S-adenosylmethionine (SAM) homeostasis is essential for methylation of biomolecules, nucleotide and polyamine synthesis, and redox balance. While all methyltransferases consume SAM, only a subset of highly tissue-specific methyltransferases regulate methylation potential. Among them, glycine N-methyltran...

Isaac Kraz, Oi-Wei Mak, Subray Hegde et al. · 0 citations

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