Derk H C Nieuwenhuijsen

Putting the brakes on muscle growth: Myostatin as regulator of disuse atrophy

Abstract Skeletal muscle is a highly plastic tissue that rapidly adapts to changes in mechanical loading and metabolic activity. Periods of inactivity, including bed rest, limb immobilization or microgravity, induce a pronounced loss of muscle mass and function. This review examines the mechanistic role of myostatin (g...