Cell-state transitions and microenvironmental remodeling in thyroid cancer progression revealed by single-cell and spatial transcriptomics
This synthesis highlights mechanisms and therapeutic hypotheses that require functional and clinical validation across localized papillary thyroid carcinoma, metastatic or radioiodine-refractory differentiated thyroid cancer (DTC), poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC).