Destiny K. Cooper

The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death.

The NLRP3 inflammasome is a central signaling pathway of innate immunity that orchestrates host defense and inflammatory responses through the activation of proinflammatory cytokines and the induction of pyroptotic cell death. Accumulating evidence indicates that NLRP3 functions within an extensive network of innate im...