Open access
Sep 2026
Pulling and gripping: Proteasomal translocation pathway elements differentially contribute to substrate unfolding
Abstract Eukaryotic proteomes are regulated by the ubiquitin‐proteasome system. Unwanted proteins are tagged with ubiquitin, which is recognized by the 26S proteasome for degradation. To enter the proteasome's 20S core particle and be hydrolyzed into peptides, the substrate must be unfolded and threaded through the 19S...
Edwin R. Ragwan, Kristin Pham, Arushi Palta et al.
· Protein Science · 0 citations