MK-801- and memantine-induced locomotor hyperactivity is attenuated by conditional loss of dopamine D2 receptors in select forebrain neurons
Disruption of cerebral cortical interneuron maturation has been implicated in the pathophysiology of schizophrenia, and NMDA receptor antagonists are widely used to model psychosis-relevant behavioral phenotypes in rodents. Dopamine D2 receptors (D2Rs) are expressed on cortical GABAergic interneurons derived from the m...