Author

Devyani Swami

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Open access Sep 2026

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

ABSTRACT Immune checkpoint inhibitors (ICIs) targeting CTLA‐4 and PD‐1 have transformed cancer therapy, yet their immune‐related adverse events (irAEs) in various tissues, including the brain, remain poorly defined. ICI perturbs hippocampal‐dependent memory function by derailing neuro‐immune homeostasis and compromisin...

Devyani Swami, Sanad M. El-Khatib, Suhas Sureshchandra et al. · Advancement of science · 0 citations

Open access Jul 2026

In vivo CRISPR base editing for treatment of Huntington's disease.

CRISPR base editors are developed that generate proteolysis-resistant HTT isoforms by disrupting the splice acceptor of HTT exon 13, an exon that encodes critical proteolytic cleavage sites implicated in N-terminal fragment production.

Shraddha Shirguppe, Michael Gapinske, Devyani Swami et al. · Nature Biomedical Engineerin... · 0 citations