Histopathology-guided spatial transcriptomic analysis identifies an ECM-associated stromal pattern in lacrimal gland adenoid cystic carcinoma with complementary proteomic and functional analyses
Background Lacrimal gland adenoid cystic carcinoma (LGACC) is a rare but locally aggressive malignancy characterized by perineural invasion, recurrence, and limited systemic treatment options. Although extracellular matrix (ECM) remodeling is increasingly recognized as an important regulator of tumor progression, its s...