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Open access Sep 2026

NKG2A-HLA-E axis contributes to an immunosuppressive checkpoint network in hepatocellular carcinoma

Abstract Background The immunosuppressive tumor microenvironment in hepatocellular carcinoma (HCC) limits the efficacy of current immunotherapies. The interplay between the emerging inhibitory receptor NKG2A and its activating counterpart NKG2C, both binding HLA-E, and its interaction with the PD-1-PD-L1 pathway in can...

Yan Li, Xiao-Mei Zhuang, Yi-Sen Tang et al. · 0 citations
Open access Aug 2026

Diverging Trajectories of Lung Cancer Burden in China, Japan, and South Korea: A Comparative Risk Assessment from the Global Burden of Disease Study 1990–2021

Lung cancer poses a major public health challenge in East Asia. This study aimed to compare the evolving burden of lung cancer and key risk factors from 1990 to 2021 in China, Japan, and South Korea, three neighboring countries with distinct socioeconomic and public health profiles.

Si-Yuan Zhao, Gang Deng, Dong Li et al. · 0 citations

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