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Open access Oct 2026

Dendrobine’s mechanism: alleviating cholesterol metabolism disorders via FXR/LXR modulation in NAFLD mouse livers

Cholesterol homeostasis is tightly regulated through hepatic synthesis, intestinal absorption, and biliary excretion, with bile acids serving as critical regulators of cholesterol catabolism. Dysregulated cholesterol metabolism and bile acid imbalance are hallmarks of non-alcoholic fatty liver disease (NAFLD), co...

Zhi Chen, Yi Luo, Yan-Zhe Xu et al. · 0 citations
Review Open access Aug 2026

Dendrobium nobile Lindl. alleviates acute alcoholic liver injury in mice by modulating bile acid metabolism via the enterohepatic circulation.

ETHNOPHARMACOLOGICAL RELEVANCE Dendrobium nobile Lindl. (DNL), a traditional Chinese medicine used for over two millennia, is attached for nourishing Yin, clearing heat, and promote fluid production. Despite its hepatoprotective potential, the underlying mechanisms need to be further explored. AIM OF THE STUDY This s...

Di Wu, Qing-Ping Yang, Ju Ye et al. · 0 citations

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