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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Di Zhao

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2 papers indexed here

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Open access Oct 2026

B7-H3-induced Myeloid–Stromal Circuit Enables Combinatorial Immunotherapy in Advanced Prostate Cancer

Advanced prostate cancer remains largely refractory to immune-checkpoint blockade, highlighting the need to understand the cellular networks that sustain immune exclusion. In a recent study, Shi and colleagues identify tumor-cell B7-H3 as a key organizer of a myeloid–stromal circuit in prostate cancer. B7-H3 activates...

Qian-Lin Gu, Di Zhao · 0 citations
Open access Sep 2026

Dual Functions of B7-H3-MAPK Signaling Orchestrate Tumor Immunosuppression via Regulating the Plasticity of Myeloid-derived Suppressor Cells and Fibroblasts

B7-H3/CD276 is an emerging immunotherapy target in cancers. However, limited knowledge of B7-H3 signaling and its role in modulating the tumor microenvironment hinders the clinical application of B7-H3-targeting therapy. Here, we report that B7-H3 plays dual roles in regulating myeloid-derived suppressor cells (MDSCs)...

Wei Shi, Ping Xu, Qian-Lin Gu et al. · 0 citations

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