Author

Dian-Ju Wei

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Oct 2026

Structure-Guided Remodeling of Multi-Substrate Binding Pocket in Nicotinamide Mononucleotide Adenylyltransferase for Efficient NAD+ Synthesis

The rational engineering of enzymes that coordinate multiple substrates within a confined active site remains a major challenge in biocatalysis. Here, we present a structure-guided dual-cluster engineering strategy that exploits low epistatic coupling among conserved residues to independently tune electronic and geom...

Dian-Ju Wei, Liang-Jun Li, Yu-Zhi Cui et al. · Journal of Agricultural and... · 0 citations

Sep 2026

Structure-guided evolution of Marinobacter subterrani deacetylase for enhanced herbicide precursor synthesis by substrate-binding pocket and channels engineering.

Deacetylases can directly hydrolyze amide bonds for the environmentally friendly synthesis of the herbicide intermediate O-(3-chloro-2-propenyl)hydroxylamine. However, the rigid halogenated chain of N-[(E)-3-chloroprop-2-enoxy]acetamide (NECA) may hinder productive substrate positioning and limit catalytic efficiency....

Yin-Feng Huang, Dian-Ju Wei, Hua-Chuan Wen et al. · Enzyme and Microbial Technol... · 0 citations