Author

Diana M. Elizondo

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Open access Sep 2026

Pde1b controls cyclic nucleotide signaling in cDC1 and macrophages to regulate immune responses.

Cyclic nucleotides cAMP and cGMP are potent suppressors of immune activation, yet how their intracellular levels are regulated within antigen-presenting myeloid cells remains undefined. Here we identify phosphodiesterase 1B (Pde1b) as a lineage-restricted regulator of cyclic nucleotide signaling in conventional type 1...

Lais Rekowsky, Ricardo L. L. da Silva, Jonathan A. Seenarine et al. · EMBO Reports · 0 citations

Jul 2026

Allograft Inflammatory Factor 1 expression in cDC1 is required to direct Tbet—driven T cell immunity to defend against intracellular pathogens in vivo 2256292

Findings identify AIF1 as a critical regulator of cDC1 immunogenic identity and protective T cell immunity to intracellular infection, defining a pathway where AIF1 loss reprograms DC—T cell communication toward a regulatory, non-protective outcome.

Lais Rekowsky, Ricardo L. L. da Silva, Jonathan A. Seenarine et al. · Journal of Immunology · 0 citations