Abstract A059: MYC biomolecular condensates contribute to PDAC classical-to-basal transition and immune evasion
MYC is one of the most ubiquitous amplified oncogenes in human cancers. Roughly 30% of pancreatic adenocarcinoma (PDAC) samples show MYC amplification, which is associated with increased aggressiveness and drug resistance. Our recent single cell analysis of 62 primary PDAC showed that MYC amplification promotes class...