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Didier Portilla

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Open access Oct 2026

Intracellular complement Factor B couples inflammatory sensing to metabolism, chromatin regulation and maladaptive tissue repair

Inflammatory signals are broadly conserved, yet how tissue context converts them into programs of recovery or maladaptive repair remains unclear. Using kidney injury as a model of inflammation-to-repair transitions, we identify an injury-induced proximal-tubule complement program in which cell-intrinsic complement prot...

Tilo Freiwald, Daniel Chauss, Md Tajmul et al. · 0 citations
Oct 2026

Programmed cell death protein 1 (PD-1) regulates metabolic activity of regulatory T cells in ischemia-induced acute kidney injury.

It is demonstrated that PD-1 knockout mice have worse renal function after IRI when compared to wild-type mice, and the metabolic vulnerability of PD-1-deficient Tregs is revealed, highlighting the critical role of PD-1 in Treg-mediated nephroprotection.

Oliver B. Pelletier, Murat Dogan, Christopher G. O'Neill et al. · 0 citations
Open access Jul 2026

A BACH2-STAT5 transcriptional module licenses a short intracellular C3 proteoform in activated CD4+ T cells 2308647

A BACH2—STAT5 transcriptional module is identified that is essential for C3 expression in activated CD4+ T cells and redirects C3 output toward a short, intracellular proteoform with noncanonical complement activity.

Jorge Trujillo, D. Chauss, Luopin Wang et al. · 0 citations

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