Open access
Aug 2026
Evaluating the impact of clinical trial design features on probability-of-success prediction
Estimating the probability of success (POS) of clinical trials remains a major challenge in drug development. Legacy forecasting approaches in the biopharmaceutical industry rely on historical averages stratified by development phase and therapy area, which obscures the contribution of trial design to clinical outcom...
Robert Howard, Beau Bush, Joseph Edelmann et al.
· Scientific Reports · 0 citations