Open access
Jul 2026
Cross-scale modeling reveals a TFRC-driven immunosuppressive macrophage niche in cervical cancer
A robust five-gene prognostic signature was developed, effectively stratifying patient survival and identifying TFRC as a pivotal metabolic-immune node through which tumor-intrinsic iron metabolism orchestrates an immunosuppressive niche, providing a foundation for novel therapeutic strategies in cervical cancer.
Yusha Chen, Ling Wang, Su-Yu Li et al.
· Frontiers in Immunology · 0 citations